Many studies have shown that mechanisms of action by DNTs to kill AML or lung cancer cell lines via various innate receptors, such as NKG2D and DNAM‐1, and releasing cytotoxic factors such as IFN‐γ and TNF‐α, thereby making target cells more susceptible to their cytotoxic activity.14, 17, 24. Here, TNF is linked to acute myeloid leukemia.