From a molecular standpoint, aberrant expression of genes such as MYCN, LIN28B, PHOX2B, and ALK contributes to the proliferation and differentiation of neuroblastoma cells, driving tumorigenesis and promoting tumor progression.30, 31, 32 Studies have shown that neuroblastoma consists of two epigenetic identities: adrenergic (ADRN) and mesenchymal (MES), which can interconvert. This evidence concerns the gene PHOX2B and neoplasm.