From a molecular standpoint, aberrant expression of genes such as MYCN, LIN28B, PHOX2B, and ALK contributes to the proliferation and differentiation of neuroblastoma cells, driving tumorigenesis and promoting tumor progression.30, 31, 32 Studies have shown that neuroblastoma consists of two epigenetic identities: adrenergic (ADRN) and mesenchymal (MES), which can interconvert. The gene discussed is PHOX2B; the disease is neuroblastoma.