Moreover, HIS treatment reversed the elevated serum levels of inflammatory factors (IL-6 and IL-17A), stress hormones (NE and COR), and 5-HT, all of which have been shown to be upregulated under chronic stress and promote tumor progression, consistent with previous research (Gao et al., 2018; Heidt et al., 2014; Chen Y. et al., 2022; Ren et al., 2018). This evidence concerns the gene IL6 and neoplasm.