E-cadherin played an important role in tissue formation, tumor suppression, and Vimentin was closely associated with increased tumor cell invasiveness and metastasis (Goyal et al., 2021; van Roy and Berx, 2008), which both were the relevant marker of Epithelial-mesenchymal transition (EMT) (Busuioc et al., 2022). This evidence concerns the gene CDH1 and neoplasm.