In the differential diagnosis, BL needs to be differentiated from other high-grade NHLs, including high-grade B-cell lymphoma, with both MYC and BCL-2, and/or BCL-6 translocations, as well as diffuse large B-cell lymphoma (DLBCL) with MYC translocation. This evidence concerns the gene BCL2 and diffuse large B-cell lymphoma.