SLC12A5 and schizophrenia: However, since the mutational landscape is being characterized, and a growing number of SLC12A5 variants are being identified, groups are beginning to understand the pathogenic consequences of heterozygous KCC2 mutations, which have been associated with psychiatric (e.g., schizophrenia) and mood disorders in GWAS studies recently (Hyde et al., 2011; Tao et al., 2012; Merner et al., 2015).