A proposed hypothesis suggests that a viral infection may trigger aberrant T and B cell activation, leading to autoimmune damage in glandular tissue [11]. Anti-SSA Ro antibodies, positive Schirmer’s test, and focal lymphocytic sialadenitis on lip biopsy provided sufficient criteria, with a score of 7, to diagnose primary SS in this patient. The gene discussed is CALR; the disease is synovial sarcoma.