In addition, the correlation analysis between TBXAS1 and immune checkpoints such as CD274, CTLA4, HAVCR2, LAG3, PDCD1, PDCD1LG2, SIGLEC15 and TIGIT showed that, in addition to thymic cancer, bladder cancer and acute myeloid leukemia, the other 30 tumors had a significant increase in the number of immune checkpoints. The gene discussed is SIGLEC15; the disease is urinary bladder cancer.