In addition to the GO terms, several significant KEGG pathways (p-value <0.05) were identified, with the most prominent being microRNAs in cancer, pathways in cancer, proteoglycans in cancer, PI3K-Akt signaling pathways, and Hepatitis B. Notably, the Glioma pathway, which includes 50 core genes, was highlighted with a Benjamini-Hochberg corrected p-value of 1.1E-27, emphasizing its relevance to GBM. This evidence concerns the gene PIK3CA and central nervous system cancer.