Additionally, the expression levels of HIF-1α target genes involved in cell survival, including Ccnd2 (encoding cyclin D2), Vegf (encoding vascular endothelial growth factor), and Bnip3l (encoding BCL2 interacting protein 3 like), were further suppressed in HIF-1αΔIEC mice under NEC stress (Figure 3C–E). The gene discussed is CCND2; the disease is necrotizing enterocolitis.