Furthermore, treatment with dimethyloxalylglycine (DMOG), a prolyl hydroxylase domain (PHD) inhibitor that stabilizes HIF-1α, alleviated NEC symptoms in HIF-1αloxP/loxP mice but had no effect on HIF-1αΔIEC mice (Figure S2A–D). The gene discussed is HIF1A; the disease is necrotizing enterocolitis.