The GO enrichment analysis showed the DEGs shared between hypothyroidism and OSA primarily play roles in functions including ERK1 and ERK2 cascade, cellular response to decreased oxygen levels, cellular response to hypoxia, inositol metabolic process, negative regulation of interleukin-1 production, neuron intrinsic apoptotic signaling pathway in response to oxidative stress, and so on (Figure 3F). The gene discussed is MAPK1; the disease is obstructive sleep apnea syndrome.