Other CD8+ T cell functional abnormalities described in adult-onset SLE include impaired Ebstein-Barr Virus (EBV)-specific responses [29–31], metabolic abnormalities linked to mitochondrial dysfunction [32, 33], and an upregulation of type I IFN-stimulated genes [20, 34]. The gene discussed is CD8A; the disease is systemic lupus erythematosus.