In summary, we tentatively conclude that LINC01094, regulated by the LINC01094-miR-128-3p-RUNX1 positive feedback loop, downregulates CDKN1A by interacting with RBMS2 and HDAC1 in the cytoplasm and nuclear, respectively, which in turn promotes malignant behaviors and poor prognosis in GC. Here, RUNX1 is linked to gastric cancer.