In the model that was adjusted for age and hypertension, the relationship identified was similar (β = −2.667, 95% CI: −5.037 to −0.298, P < 0.05), and in the model that was adjusted for age, hypertension, nuclear fragmentation, mesangial cell and matrix proliferation, microthrombi, ALB, serum C3, 24-hour proteinuria, endothelial hyperplasia and Hb, the relationship remained (β = −2.852, 95% CI: −5.161 to −0.543, P < 0.05). The gene discussed is C3; the disease is Hypertension.