IL4 and lobular neoplasia: This finding suggests that the basophil count might be a predictor of greater renal activity of LN and relatively severe renal damage.22 A potential explanation for this correlation is the involvement of basophils in the pathogenesis of LN through the production of T-helper 2-derived proinflammatory cytokines, such as interleukin-4 and thymic stromal lymphopoietin.