Taken together, these findings demonstrated the important roles of the CXCL10/CXCR3 axis in modulating the JAK/STAT3 pathway and inducing neuroinflammation to mediate pain in chronic prostatitis, and targeting the NGF/TrKA pathway showed therapeutic efficacy in pain treatment in chronic prostatitis (Figure 8). This evidence concerns the gene NTRK1 and chronic prostatitis.