EME1 and neoplasm: Additionally, we found support for the SL interaction between LIG1 and PARP1 and EME1 and PARP1 by analyzing the coexpression of LIG1, EME1, or FAAP24 and PARP1 in relation to the tumor, node, metastasis (TNM) stage of PCa samples (P value for LIG1-PARP1 < 0.001; P value for EME1-PARP1 < 0.05) (Supplemental Figure 2C).