LIG1 and low grade glioma: High incidence of hemizygous deletions (hemidel) and copy-neutral loss of heterozygosity (CN-LOH) events in LIG1 characterized low-grade glioma (LGG), OV, and lung adenocarcinoma (LUAD) among others, while homozygous deletions (homodel) and deleterious single nucleotide variants (SNVs) were detected in a small fraction of several tumor types (Figure 5A).