AR and posterior cortical atrophy: 22Rv1 and DU145 PCa cell lines showed similar responses to PARPi and were selected based on the AR status (22Rv1 cells are AR positive while DU145 cells are AR negative) to mimic CRPC states and the absence of biallelic loss-of-function alterations in DRG previously associated with PARPi sensitivity (Supplemental Figure 1, A and B).