To determine if a loss in lysosomes was also present in NK cells of individuals W/O, we performed RT-qPCR analysis (Figure 5J) and found that LAMP1 mRNA expression was 45.8% ± 3% reduced when compared with individuals WO/O, highlighting the similarities between hyperlipidemia and obesity in NK cells (Figure 5K). The gene discussed is LAMP1; the disease is obesity due to melanocortin 4 receptor deficiency.