CRBN and pancreatic ductal adenocarcinoma: We previously demonstrated that our dTAG molecules known as dTAGV-1 and dTAG-13, which recruit von Hippel-Lindau (VHL) or cereblon (CRBN), respectively, are selective and degrade KRASG12V in several cellular models, including pancreatic ductal adenocarcinoma cell lines (27, 28).