HCRTR1 and Anorexia: The mechanisms of improvement in anorexia with ninjin’yoeito include activation of the ghrelin-responsive and ghrelin-unresponsive neuropeptide Y pathways and orexigenic orexin 1 receptor-expressing neurons in the hypothalamus, and the promotion of increasing intracellular dopamine content by inhibiting metabolic enzymes [30–32].