CACNA1D and clostridium difficile infection: Moreover, the automodulatory C-terminal domain of the long CaV1.3 isoform, abundant at the IHC ribbon synapses (Bock et al., 2011; Scharinger et al., 2015), does not seem critical for CDI suppression either, as its disruption does not lead to hearing impairment (Scharinger et al., 2015).