Given that TAZ levels did not significantly differ between healthy and tumour tissues, and that TEAD1 could not discriminate between LGG and GBM tissues, we chose here to specifically assess the importance of the Hippo/YAP1 signalling in the highest aggressive type of brain cancer that GBM represents and where in silico analysis of YAP1 revealed significant and specific increases in clinically annotated GBM tissues. This evidence concerns the gene TEAD1 and brain cancer.