Despite normal ad libitum chow intake, MC3R KO mice are hypersensitive to a remarkably diverse array of anorexic stimuli including stress‐related anorexia (restraint stress and social isolation) (Sweeney et al., 2021), diverse forms of pharmacological anorexia (Dahir et al., 2024; Ghamari‐Langroudi et al., 2018; Sweeney et al., 2021) (i.e. administration of GLP1R agonists, leptin, MC4R agonists, peptide YY and cholecystokinin) and physiological anorexia (i.e. tumour cachexia) (Marks & Cone, 2003; Marks et al., 2003). The gene discussed is LEP; the disease is Anorexia.