AP2S1 and Alzheimer disease: They are associated with AD41 and frontotemporal dementia and are considered targets for AD therapeutics.42 Our analysis of sigma receptors showed no statisticaldifferences between conditions or cell types but instead a tendencytoward less total ligand-binding to sigma-1 and sigma-2 receptorsin neurons compared to astrocytes in the control situation (Figure 6A; 7727 ± 1864and 11232 ± 3207 O.D/ng immobilized protein, respectively).