ADGRA3 and obesity due to melanocortin 4 receptor deficiency: To identify whether Adgra3 overexpression induces adipose thermogenesis and improves the metabolic homeostasis against obesity, Adgra3 OE and CON were injected i.p. into mice fed with a NCD (Figure 4—figure supplement 1A) and a HFD (Figure 4A), thereby establishing models of Adgra3-overexpressed mice (Figure 4F-G, Figure 4—figure supplement 1B-C).