Meanwhile, hematoxylin-eosin staining showed that Adgra3 knockdown induced adipose expansion in iWAT (Figure 3—figure supplement 1F), eWAT (Figure 3—figure supplement 1G), and BAT (Figure 3—figure supplement 1F) but not lead to hepatic steatosis (Figure 3—figure supplement 1G). Here, ADGRA3 is linked to fatty liver disease.