CD274 and neoplasm: Given their overlapping roles in increasing TILs and in particular their complement roles in inducing MHC-I and PD-L1 expression on tumor cells, which turn tumors hot and more sensitive to PD-1 blockade, combination of nanoPDLIM2 and chemotherapeutic drugs with anti-PD-1 is expected to show better efficacy compared to combining only two of them.