RELA and cancer: One most important function of PDLIM2 is to promote the ubiquitination and proteasomal degradation of nuclear signal transducer and activator of transcription 3 (STAT3) and nuclear factor-κB (NF-κB) RelA (also known as p65), two master transcription factors that function as proto-oncogenes in lung and many other cancers (Sun et al., 2019; Guo and Qu, 2021; Qu et al., 2010a; Qu et al., 2010b; Sun et al., 2015; Tanaka et al., 2007; Qu et al., 2012; Zhou et al., 2015; Qu et al., 2015; Steinbrecher et al., 2008; Yu et al., 2009; Xiao and Fu, 2011).