Peptidyl-tRNA hydrolase 1 homolog (PTRH1), another inhibitory RBP, suppressed PD-L1 expression by binding to the 3'-UTR of PD-L1 mRNA, thereby enhancing CD8+ T cell infiltration and improving their cytotoxic efficacy in pancreatic cancer [42]. Here, CD274 is linked to familial pancreatic carcinoma.