BIRC2 and digestive system neoplasm: Firstly, HuR is a widely expressed RBP in GI tumours and binds to transcripts of components of the TNF receptor (TNFR) complex, such as inhibitor of apoptosis protein 1 (IAP1) and inhibitor of apoptosis protein 2 (IAP2), which regulate NF-κB signalling downstream of multiple TNF superfamily receptors in immune cells [34,44].