ARF6 and pancreatic ductal adenocarcinoma: Additionally, eukaryotic translation initiation factor 4a (EIF4A) and eukaryotic translation initiation factor 4e (EIF4E) regulated mRNAs stability and promoted the translation of small GTPase ADP-ribosylation factor 6 (ARF6) and its downstream effector multiple-domain Arf-GAP protein 1 (AMAP1) in pancreatic ductal adenocarcinoma (PDAC), driving PD-L1 recycling and surface expression following receptor tyrosine kinase (RTK) activation [38].