However, there were interactions of IL-18 and HCC (ΔR2 = 4.7%, F(1, 90) = 4.965, p < .05), and of IL-18, Age, and HCC (ΔR2 = 10.6%, F(2, 90) = 5.546, p < .01). Here, IL18 is linked to hepatocellular carcinoma.