CD4 and hepatocellular carcinoma: However, there was an interaction of the CD4/CD8 ratio with HCC (F(5, 180) = 4.30, p < .05), showing a moderation of the relationship HCC – OLBI for low ratios of CD4/CD8 in all participants groups (p < .05 to p < .001), in middle-aged and older participants for intermediate ratios (p < .001), and for highest ratios in older adults only (p < .05), although the interaction with Age did not reach significance (F(2, 181) = 2.45, p = .092, Fig. 8a).