Knockdown of FRMD6-AS1 significantly increased iron ion, ROS, and MDA levels in activated HSCs while reducing GSH levels and the expression of SLC7A11 and GPX4 proteins, inducing ferroptosis in HSCs, thereby restoring liver tissue structure and reversing liver fibrosis (Li Z. et al., 2024). This evidence concerns the gene FRMD6 and Hepatic fibrosis.