Upon external stimulation, Nrf2 translocates to the hepatocyte nucleus and activates downstream molecules such as heme oxygenase-1 (HO-1), inhibiting ROS production and thereby preventing ferroptosis and liver injury (Yang et al., 2022).To date, the role of ferroptosis-related circRNA, particularly its association with liver fibrosis, has not been fully elucidated. Here, HMOX1 is linked to Hepatic fibrosis.