PIR and acute myocardial infarction: Moreover, the piRNAs, namely, piR-hsa-9010, piR-hsa-28646, and piR-hsa-23619 are significantly upregulated in acute myocardial infarction (AMI) patients, with piR-hsa-28646 and piR-hsa-23619 showing higher expression in Primary Human Umbilical Vein Endothelial Cells (HUVEC) (Figure 8A), with involvement in key signalling pathways such as Wnt and TNF signalling.