Hadland et al. identified VE-cadherin+CD61+EPCR+ cells as a precursor to functional HSCs (Hadland et al., 2022), Vink et al. reported that the earliest functional HSCs are marked by CD27 (Vink et al., 2020), and Menegatti et al. identified CD82 as a novel surface marker specific to EHT (Menegatti et al., 2023). Here, CDH5 is linked to essential hypertension, genetic.