Indeed, treatment with an RSV-supplemented diet (500 mg/kg/day) for 32 weeks starting at 9 weeks of age inhibited cardiac hypertrophy and fibrosis and improved cardiac function in the mdx heart and concomitantly downregulated the protein levels of p300, an acetyltransferase that promotes adaptive cardiac hypertrophy (Kuno et al., 2013). Here, EP300 is linked to cardiac hypertrophy.