In contrast, abnormally enhanced NKCC2-mediated NaCl reabsorption is associated with hypertension in humans (Aviv et al., 2004; Jung et al., 2011; Gonzalez-Vicente et al., 2019) and animal models (Haque et al., 2011; Ares et al., 2012; Capasso et al., 2005; Sonalker et al., 2007) of spontaneous and salt-sensitive hypertension (Ortiz et al., 2003). This evidence concerns the gene SLC12A1 and Hypertension.