In a direct comparison with a spectrum of pan-cancer signatures, including INFG.Sig (26), T.cell.inflamed.Sig (26), PDL1.Sig (27), LRRC15.CAF.Sig (28), NLRP3.Sig (29), and Cytotoxic.Sig (30), Necroptosis.Sig emerged as the most effective predictor in the testing set, achieving an AUC of 0.74, with INFG.Sig trailing closely behind at an AUC of 0.66 (Figure 3A). This evidence concerns the gene NLRP3 and cancer.