In breast cancer cells, the expression of TMEM176B is crucial for AKT/mTOR signaling, angiogenesis, KRAS signaling, epithelial−mesenchymal transition (EMT), and the regulation of estrogen and interferon response genes (62), therefore, therapeutic antibodies that target TMEM176B may inhibit tumor cell proliferation. The gene discussed is TMEM176B; the disease is breast carcinoma.