MyCAFs are related to the ECM and can synthesize collagen to mediate ECM remodeling; iCAFs mainly secrete various cytokines, growth factors, and chemokines to regulate tumor immune suppression; apCAFs induce naive CD4 T cells to differentiate into regulatory T cells (Tregs) in an antigen-specific manner; rCAFs are the most special and play a role in inhibiting tumor growth. Here, CD4 is linked to neoplasm.