IL-8 originating from CAFs initiates the NF-κB signaling pathway in pancreatic cancer cells, with P65 binding to the promoter region to boost the transcription of UPK1A-AS1, which acts as a molecular scaffold for Ku70 and Ku80, thereby augmenting the cell’s DNA repair capabilities (78). This evidence concerns the gene CXCL8 and familial pancreatic carcinoma.