Also in conjunction with the subtypes of TCs, C2 MUC2+ TCs, C4 OTOP2+ TCs, and C5 SLC26A3+ TCs subtypes were concentrated in early developmental trajectories, whereas C1 APCDD1+ TCs, C3 HEPACAM2+ TCs, and C6 AVIL+ TCs were concentrated in late developmental trajectories, and unlike C0 FXYD5+ TCs subtype, it was found in mid- to late-developmental trajectories; for the tissue origin, normal and para-cancer tissues were present at the initial developmental stage, which later i.e., developed into the adenoma and carcinoma. This evidence concerns the gene OTOP2 and carcinoma.