Meanwhile, SELENBP1 was also noteworthy, as it was highly expressed in C1 APCDD1+ TCs, and studies had shown that it was down-regulated in CRC but not in normal tissue or adenoma tissue (87), a typical oncogene that inhibits colorectal cancer progression by suppressing the EMT (88), whereas it was low-expressed in C0 FXYD5+ TCs, reflecting its intermediary role in the progression from C1 APCDD1+ TCs to C0 FXYD5+ TCs (Figure 2D). Here, FXYD5 is linked to colorectal carcinoma.