HAVCR2 and neoplasm: Tex cells exhibit elevated inhibitory receptors (PD-1, CTLA-4, TIM-3, TIGIT, LAG-3), reduced antitumor cytokines (IFN-γ, IL-2, TNF) (6, 11, 12), increased tumor-promoting chemokines, altered transcription factors (TCF1, T-bet, TOX), metabolic issues, and decreased proliferation and survival (6, 11).