NFKB1 and urinary bladder cancer: Importantly, TAMs, influenced by NF-κB signals, are known to promote and mediate angiogenesis through the production of interleukins like IL-10, VEGF, and IL-8, making NF-κB a viable target for treating cancers such as urinary bladder cancer (UBC) (Iacona and Lutz, 2019).