SELPLG and malignant colon neoplasm: Because of the requirement for interaction between PSGL-1 on cancer cells and Selectin binding on the vascular endothelium after entry of the cancer cells into the bloodstream, this result holds implications for tethering and rolling processes in lung and colon cancers, shedding light on how increased PSGL-1 expression may impact the interactions between cancer cells and their microenvironment.