As NRF2 is known to be upregulated by arsenic, a study aimed to determine whether elevated NRF2 levels can promote lung cancer cells’ ability to migrate via a mechanism involving SOX9 transcription factor in A549 and H1299 NSCLC, as well as immortalized lung epithelial BEAS-2B cell lines. This evidence concerns the gene SOX9 and non-small cell lung carcinoma.