STAT3 and non-small cell lung carcinoma: Besides, PROS downregulated the antiapoptotic Bcl-2 protein, activation of ERK, Src, and AKT as well as cell cycle regulating genes (Cyclin E, Cyclin A, CDK2), E2F1, IL-6, COX-2, and SOCS-1, and impaired STAT3 ability to bind with CDK2 and VEGF in H1299, A549, H460 NSCLC cell lines[50].