The abnormal expression of GATA6 may also affect the pancreas development and carcinogenesis via Wnt, Notch, hedgehog, transforming growth factor-β (TGF-β), and vascular endothelial growth factor receptor (VEGFR) signaling pathways (Fig. 2), which play crucial roles in the initiation and progression of pancreatic cancer. Here, GATA6 is linked to pancreatic neoplasm.