The expression of vascular endothelial growth factor (VEGF) is tightly regulated by PI3K/mTOR,53 which not only promotes tumor vascularization but also enhances the infiltration of regulatory immune cells, including myeloid-derived suppressor cells (MDSCs),54,55 tumor-associated macrophages (TAM),56,57 and regulatory T cells.58 Here, PIK3CA is linked to neoplasm.