REN and liver dysplastic nodule: ,2 The clinical manifestations of DN encompass progressive proteinuria, reduced glomerular filtration rate,3 glomerular hypertrophy, thickening of the glomerular basement membrane, mesangial hyperplasia, and podocyte loss.4, 5, 6 Currently, the management of DN primarily involves nutritional interventions and control of blood glucose and hypertension, including the administration of hypoglycemic agents that directly impact renal function and drugs that inhibit the renin-angiotensin system.7