MTOR and renal fibrosis: Additionally, miR-29c promotes DN renal fibrosis by activating the AMPK/mTOR signaling pathway, while overexpression of miR-136 down-regulates spleen tyrosine kinase and inhibits the transforming growth factor β1/Smad3 signaling pathway, leading to increased expression of mTOR and mediating renal tubular epithelial cell fibrosis.75