α-melanocyte-stimulating hormone (α-MSH), critical in satiety and anxiety signal transduction, is influenced by caseinolytic protease B (ClpB) produced by Escherichia coli and other Enterobacteriaceae, highlighting ClpB as a potential mediator in anxiety regulation through gut microbiota (Navarro-Tapia et al., 2021). Here, CLPB is linked to Anxiety.