OXTR and Anxiety: Indeed, we have identified strain- and age-dependent differences of OXTR binding in various brain regions that are critically involved in anxiety-like behavior, conditioned fear and social behavior (Figure 5; Brandão et al., 2008; Calhoon and Tye, 2015; Menon et al., 2022; Zhao et al., 2009; Zoicas et al., 2014).