OXTR and Anxiety: Whereas the LS is essentially modulating social behavior including social fear extinction (Menon et al., 2022), the VMH is particularly involved in anxiety and fear responses (Zhao et al., 2009) and the PAG in fear, flight and freezing responses (Brandão et al., 2008; Tovote et al., 2015; Tovote et al., 2016; Zhao et al., 2009), leading to the hypothesis that differences in local OXTR binding might contribute to the observed strain and age differences in socio-emotional behavior (see Figures 1–4).