Second, although both neural classes identified herein were clearly associated with stronger (cholinergic-oriented) or weaker (adrenergic-oriented) pathogenic HCC phenotypes, where higher ADRA2B expression is related to good prognosis,34 proteomic confirmation of these findings on a large set of ethnically diverse patients21 will be necessary to confirm RNA data. The gene discussed is ADRA2B; the disease is hepatocellular carcinoma.