To characterize HCC innervation, the following classically validated neuron markers were considered: neuronal nuclear antigen (NeuN, phospho- and total, RBFOX3) as a mature, nuclear, neuron marker;16 and doublecortin (DCX) and internexin neuronal intermediate filament protein alpha (INA) as immature neuron markers.17 The gene discussed is RBFOX3; the disease is hepatocellular carcinoma.