Spermatogenesis associated 3 (SPATA33) has been identified as a putative melanoma susceptibility gene (Fang et al., 2020); it is also associated with Fanconi anemia, a rare genetically heterogeneous recessive disorder with variable clinical manifestations, including cutaneous pigmentary alterations such as widespread areas of hyper- and hypo-pigmentation of the skin in characteristic patterns and café-au-lait spots (Ogilvie et al., 2002; Ruggiero et al., 2021). This evidence concerns the gene SPATA3 and melanoma.