Karolack et al. reported an accumulation of sequence variants in the Wnt signaling pathway and identified a missense variant rs387907358 (c.1063G > T, p.(V355F)) in the WNT1 gene in corneal tissue of Polish KC patients suggesting a potential role in KC (Karolak et al., 2020b). The gene discussed is WNT1; the disease is keratoconus.