Since the genetic etiology of KC is heterogeneous with multiple genes underlying its pathogenesis, the study aimed to investigate the association of these specific genetic polymorphisms (rs2371597 in STON2, rs11720822 in PDIA5, rs387907358 in WNT1, and rs77542162 in ABCA6) with KC in a cohort of Saudi patients. This evidence concerns the gene STON2 and keratoconus.