The low allele frequency or absence of the rs11720822 [T] variant in PDIA5 and the rs387907358 [T] and rs77542162 [G] variants in WNT1 and ABCA6, respectively, among KC patients of Saudi origin suggests that these particular variants might not be significant risk factors for KC in Saudi individuals. The gene discussed is WNT1; the disease is keratoconus.