CRP and clostridium difficile infection: Classical risk factors for developing a severe form of CDI are older age, increased leucocyte count (over 15000 cells/mmc), increased creatinine (over 1.5 mg/dl), decreased albumin (below 3 g/dl), increased markers of inflammation (C-reactive protein (CRP)), and the use of antibiotics and proton pump inhibitors (PPI) [24,25].