Fig. 2 visualizes a suggested work-up in older patients with hypertension: in all patients with OH, in addition to optimal hypertension treatment with an ACE-inhibitor or CCB, information on OH and explanation of possible counter-manoeuvres, such as standing up slowly, crossing the legs and tightening the glute muscles should be given, and volume repletion should be ensured. The gene discussed is ACE; the disease is hypertensive disorder.